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Clinical Trial
. 1996 Nov;23(13):1787-91.

[Evaluation of hepatic arterial infusion chemotherapy for gastric cancer]

[Article in Japanese]
T Uemura  1 , S Kawasaki, H Kawai, M Suga, S Maruyama, J Otani, S Morisue, K Yoshizane, Y Morokoshi, M Yamamoto, M Soda
Affiliations
  • PMID: 8937489
Clinical Trial

[Evaluation of hepatic arterial infusion chemotherapy for gastric cancer]

[Article in Japanese]
T Uemura et al. Gan To Kagaku Ryoho. 1996 Nov.

Abstract

Hepatic arterial infusion chemotherapy (HAIC) using implantable reservoir was performed for liver metastases of gastric cancer and the therapeutic effects were evaluated. A catheter was placed in the hepatic artery via left subclavian artery or by direct insertion at laparotomy. Cisplatin, adriamycin and 5-FU were administered. The liver metastases of gastric cancer without unresectable primary tumors and hepatectomy were divided into two groups, 16 HAIC cases (11 synchronous, 5 metachronous metastases) and 23 systemic chemotherapeutic cases (10 synchronous, 13 metachronous metastases). As a result, HAIC revealed a 62.5% response rate. The 50% survival period was 395 days for HAIC, and it was significantly prolonged compared with 198 days for systemic chemotherapy (p < 0.01). But 4 among 10 cases responding to HAIC showed subsequent extrahepatic spread of the disease. Treatment of these extra-hepatic lesions is difficult.

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