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Review
. 1996 Oct;8(5):670-8.
doi: 10.1016/s0955-0674(96)80108-6.

Desmosomes: differentiation, development, dynamics and disease

D Garrod  1 , M Chidgey, A North
Affiliations
Review

Desmosomes: differentiation, development, dynamics and disease

D Garrod et al. Curr Opin Cell Biol. 1996 Oct.

Abstract

Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate the adhesive properties of desmosomes in epithelial cell sheets. Genetic studies indicate the involvement of desmosomal components in cancer and epidermal diseases.

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