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Review
. 1996 Oct;3(10):791-801.
doi: 10.1016/s1074-5521(96)90063-0.

Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions

J E Ladbury  1 , B Z Chowdhry
Affiliations
Review

Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions

J E Ladbury et al. Chem Biol. 1996 Oct.

Abstract

Biomolecular interactions can be defined by combining thermodynamic data on the energetic properties of the interaction with high-resolution structural data. The development of high sensitivity isothermal titration calorimetric equipment provides a dramatic advance in the gathering of thermodynamic data, and the interactions between biological macromolecules can now be described with unprecedented accuracy.

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