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. 1996 Dec 6;274(5293):1732-6.
doi: 10.1126/science.274.5293.1732.

DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode

J D Lieb  1 , E E Capowski, P Meneely, B J Meyer
Affiliations

DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode

J D Lieb et al. Science. .

Abstract

The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).

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