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. 1996 Dec 5;384(6608):432-8.
doi: 10.1038/384432a0.

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

E J Wiertz  1 , D Tortorella, M Bogyo, J Yu, W Mothes, T R Jones, T A Rapoport, H L Ploegh
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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

E J Wiertz et al. Nature. .

Abstract

The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.

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