Are particular Epstein-Barr virus strains linked to disease?
- PMID: 8946605
- DOI: 10.1006/scbi.1996.0028
Are particular Epstein-Barr virus strains linked to disease?
Abstract
The presence of the well-established EBV types (type 1 and 2) in cancers seems merely to reflect their prevalence in the population; the EBNA genes which determine type 1 and 2 are not usually expressed in cancers. In contrast, LMP1 is frequently expressed in nasopharyngeal carcinoma and a variant form of LMP1 has been linked with this disease. This form of LMP1 is also more transforming in cell culture assays. Many other examples of minor sequence variation have been reported but there is no evidence that they are of functional importance in EBV-associated disease.
Similar articles
-
Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A, -3B, and -3C genes.Virus Res. 2006 Jun;118(1-2):105-14. doi: 10.1016/j.virusres.2005.11.020. Epub 2006 Jan 6. Virus Res. 2006. PMID: 16406167
-
Association between EBNA2 and LMP1 subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais.J Clin Virol. 2008 May;42(1):1-6. doi: 10.1016/j.jcv.2007.11.011. Epub 2008 Jan 3. J Clin Virol. 2008. PMID: 18180201
-
Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity.J Clin Virol. 2006 Jun;36(2):119-25. doi: 10.1016/j.jcv.2006.01.018. Epub 2006 Apr 17. J Clin Virol. 2006. PMID: 16616610
-
Epstein-Barr Virus and Cancer.Annu Rev Pathol. 2019 Jan 24;14:29-53. doi: 10.1146/annurev-pathmechdis-012418-013023. Epub 2018 Aug 20. Annu Rev Pathol. 2019. PMID: 30125149 Review.
-
Role of Epstein-Barr virus gene latent membrane protein in nasopharyngeal carcinoma.Trends Microbiol. 1996 Apr;4(4):132-3. doi: 10.1016/0966-842x(96)30014-0. Trends Microbiol. 1996. PMID: 8728605 Review. No abstract available.
Cited by
-
Immune Control of γ-Herpesviruses.Viral Immunol. 2020 Apr;33(3):225-232. doi: 10.1089/vim.2019.0080. Epub 2019 Jul 22. Viral Immunol. 2020. PMID: 31334688 Free PMC article.
-
Epstein-barr virus sequence variation-biology and disease.Pathogens. 2012 Nov 8;1(2):156-74. doi: 10.3390/pathogens1020156. Pathogens. 2012. PMID: 25436768 Free PMC article. Review.
-
The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: a need for reappraisal.Virus Res. 2009 Aug;143(2):209-21. doi: 10.1016/j.virusres.2009.07.005. Epub 2009 Jul 23. Virus Res. 2009. PMID: 19596032 Free PMC article. Review.
-
Conservation of Epstein-Barr virus cytotoxic T-cell epitopes in posttransplant lymphomas: implications for immune therapy.Am J Pathol. 2002 May;160(5):1839-45. doi: 10.1016/S0002-9440(10)61130-3. Am J Pathol. 2002. PMID: 12000735 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources