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. 1996 Nov 15;15(22):6166-71.

A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL

S Philipp  1 , A Cavalié, M Freichel, U Wissenbach, S Zimmer, C Trost, A Marquart, M Murakami, V Flockerzi
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A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL

S Philipp et al. EMBO J. .

Abstract

Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP3)-mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry. Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP3 or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP3 signalling.

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