[Activity of enzymes controlling adenosine metabolism in ischemic heart disease]

Abstract

It is shown that patients with acute myocardial infarction and with chronic coronary insufficiency present an elevated 5'-nucleotidase and adenosine-desaminase activity. In clinically healthy persons examined after a physical exercise test the activity of 5'-nucleotidase and adenosine-desaminase declines. In most patients with chronic coronary insufficiency an increased activity of enzymes responsible for the metabolism of adenosine, above all of 5'-nucleotidase, is registered after a graded physical exertion test.