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Case Reports
. 1996 Sep;135(3):443-7.

Autoantibodies to bullous pemphigoid and epidermolysis bullosa acquisita antigens in an infant

Y Kawachi  1 , M Ikegami, T Hashimoto, K Matsumura, T Tanaka, F Otsuka
Affiliations
  • PMID: 8949441
Case Reports

Autoantibodies to bullous pemphigoid and epidermolysis bullosa acquisita antigens in an infant

Y Kawachi et al. Br J Dermatol. 1996 Sep.

Abstract

We describe a 1-year-old boy with multiple tense blisters on the skin, who showed circulating autoantibodies directed to both bullous pemphigoid and epidermolysis bullosa acquisita antigens. The patient's serum IgG antibodies bound to the 290-kDa epidermolysis bullosa acquisita antigen with immunoblot analysis of human dermal extracts. Immunoblot analysis also demonstrated that the patient's serum autoantibodies were reactive with recombinant NC16a domain of the 180-kDa bullous pemphigoid antigen. This study confirmed the presence of circulating autoantibodies directed to both bullous pemphigoid antigen and epidermolysis bullosa acquisita antigen.

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