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. 1996 Dec 20;274(5295):2063-5.
doi: 10.1126/science.274.5295.2063.

Molecular Basis of Gene-for-Gene Specificity in Bacterial Speck Disease of Tomato

SR Scofield  1 , CM Tobias, JP Rathjen, JH Chang, DT Lavelle, RW Michelmore, BJ Staskawicz
Affiliations

Molecular Basis of Gene-for-Gene Specificity in Bacterial Speck Disease of Tomato

SR Scofield et al. Science. .

Abstract

Transient expression of the Pseudomonas syringae avirulence gene avrPto in plant cells resulted in a Pto-dependent necrosis. The AvrPto avirulence protein was observed to interact directly with the Pto resistance protein in the yeast two-hybrid system. Mutations in the Pto and avrPto genes which reduce in vivo activity had parallel effects on association in the two-hybrid assay. These data suggest that during infection the pathogen delivers AvrPto into the plant host cell and that resistance is specified by direct interaction of Pto with AvrPto.

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