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. 1996 Nov 4;738(2):353-6.
doi: 10.1016/s0006-8993(96)01049-9.

Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats

J Larson  1 , C N Quach, B Q LeDuc, A Nguyen, G A Rogers, G Lynch
Affiliations

Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats

J Larson et al. Brain Res. .

Abstract

The present study tested if a positive modulator of AMPA-type glutamate receptors would counteract the behavioral effects of a drug that enhances the release of dopamine. BDP-29, a compound shown to increase AMPA receptor-mediated synaptic responses in hippocampal slices, markedly attenuated the amount of stereotypic rearings seen in rats after methamphetamine injections. These results suggest that AMPA receptor modulators ameliorate certain aberrant, dopamine-related behaviors and hence may be of interest with regard to schizophrenia.

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