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Review
. 1996:91 Suppl 2:85-90.
doi: 10.1007/BF00795368.

Activated tissue renin-angiotensin systems add to the progression of heart failure

Y M Pinto  1 , H Buikema, W H van Gilst, K I Lie
Affiliations
Review

Activated tissue renin-angiotensin systems add to the progression of heart failure

Y M Pinto et al. Basic Res Cardiol. 1996.

Abstract

In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin systems are activated in heart failure; c) activated tissue renin-angiotensin systems induce cardiovascular dysfunction. Finally, this hypothesis predicts that optimal treatment in heart failure requires the inhibition of tissue renin-angiotensin systems. However, studies pertaining to this prediction are still lacking, particularly in human subjects.

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