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. 1996 Nov;89(3):419-23.
doi: 10.1046/j.1365-2567.1996.d01-764.x.

Thymocyte emigration in the chicken: an over-representation of CD4+ cells over CD8+ in the periphery

K Katevuo  1 , O Vainio
Affiliations

Thymocyte emigration in the chicken: an over-representation of CD4+ cells over CD8+ in the periphery

K Katevuo et al. Immunology. 1996 Nov.

Abstract

We have examined the emigration of chicken thymocytes after intrathymic fluorescein isothiocyanate (FITC) labelling in situ. In this paper we show that in young birds about 0.7% and 0.4% of thymocytes emigrate from the thymus to the blood and the spleen, respectively, per day. This suggests that, as in mammals, most thymocytes die within the thymus. At 3 weeks of age gamma delta and alpha beta T cells leave the thymus in comparable levels to their appearance in the blood. The phenotype of recent emigrants in peripheral tissues is similar to that of mature T cells. Interestingly, recent emigrants contain relatively much higher numbers of CD4+ and fewer CD8+ cells than is observed in peripheral tissues in a steady-state situation.

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