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. 1996 Dec;39(12):2046-51.
doi: 10.1002/art.1780391214.

Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus

K E Sullivan  1 , C Wooten, D Goldman, M Petri
Affiliations

Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus

K E Sullivan et al. Arthritis Rheum. 1996 Dec.

Abstract

Objective: To determine whether dysfunctional or deficient mannose-binding protein (MBP) variants are found with increased frequency in black patients with systemic lupus erythematosus (SLE) compared with controls.

Methods: Allele-specific polymerase chain reaction amplification of 4 different polymorphic sites was performed on samples from 92 black SLE patients and 86 geographically matched black controls.

Results: Two structural polymorphisms of MBP, associated with low serum levels of MBP, were found with significantly increased frequency in the SLE patient population compared with controls. In contrast, a promoter haplotype associated with particularly high serum levels of MBP was negatively associated with SLE.

Conclusion: Deficiencies of MBP predispose individuals to SLE.

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