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. 1996 Dec 10;93(25):14304-7.
doi: 10.1073/pnas.93.25.14304.

Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival

R K Chandra  1
Affiliations

Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival

R K Chandra. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Malnutrition was induced in 8-week-old C57BL/6 × DBA/2 F1 hybrid male mice fed approximately 40% of nutrient requirement for 3 weeks, and the animals were divided into two groups. One group received a feeding formula that was enriched in those nutrients known to stimulate immune responses; the second group received a control formula. After 2 weeks of formula feeding, the mice were challenged with 4 × 104 L. monocytogenes intraperitoneally. Survival was observed, and the number of bacteria in the liver and the spleen were counted. (Left) More mice survived in the enriched formula group (▪) compared with the control (•) on days 3, 5 (P < 0.05), 7 (P < 0.02), and 10 (P < 0.02) postchallenge. (Right) The number of Listeria in both the spleen (P < 0.01) and the liver (P < 0.05) was lower in the enriched formula fed group (solid bars) compared with the control (open bars). CFU, colony-forming units.
Figure 2
Figure 2
Histological examination of the liver showed focal areas of hepatocyte necrosis, mononuclear and neutrophilic infiltrate, and apoptotic liver cells in animals fed control formula (Upper Right); the necrotic liver cells appeared fuzzy. (Upper Left) In contrast, the normal lobular architecture and hepatocyte appearance was preserved in animals on enriched formula. (Hematoxylin/eosin ×20.) (Lower Left) The spleen of animals on the control formula showed subcapsular foci of granulomatous inflammation populated mainly by macrophages and paucity of lymphoid follicles. There was evidence of cellular necrosis. (Lower Right) In contrast, the spleen of animals fed the enriched formula showed dense mononuclear cell aggregates and absence of necrotic granuloma. (Hematoxylin/eosin ×10.)
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References

    1. Chandra R K. Am J Clin Nutr. 1991;53:1087–1101. - PubMed
    1. Chandra R K. Nutrition and Immunology. St. John’s, Newfoundland, Canada: ARTS Biomedical; 1992. pp. 9–43.
    1. Scrimshaw N S, Taylor C E, Gordon J E. Interactions of Nutrition and Infection. Geneva: W.H.O.; 1968. - PubMed
    1. Chandra R K. Lancet. 1983;i:688–691. - PubMed
    1. Chandra R K, Newberne P M. Nutrition, immunity and infection: Mechanisms of interactions. New York: Plenum; 1977.