Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Dec 10;93(25):14771-5.
doi: 10.1073/pnas.93.25.14771.

A metric map of humans: 23,500 loci in 850 bands

A Collins  1 , J Frezal, J Teague, N E Morton
Affiliations

A metric map of humans: 23,500 loci in 850 bands

A Collins et al. Proc Natl Acad Sci U S A. .

Abstract

High-resolution maps integrated with the enhanced location data base software (LDB+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter-Falconer levels, as in Drosophila and the mouse. The autosomal genetic map is 2832 and 4348 centimorgans in males and females, respectively. Telomeric T-bands are strikingly associated with male recombination and gene density. Position and centromeric heterochromatin have large effects, but nontelomeric R-bands are not significantly different from G-bands. Several possible reasons are discussed. These regularities validate the maps, despite their high resolution and inevitable local errors. No other approach has been demonstrated to integrate such a large number of loci, which are increasing at about 45% per year. The maps and the data and software from which they are constructed are available through the Internet (http:@cedar.genetics.soton.ac.uk/public_html). Successive versions of this location data base may also be accessed on CD-ROM.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mapped genes by year. During this time mapping standards and gene definitions have changed: 1979–1983, autosomal confirmed and provisional (1); 1985–1993, polymorphic genes and D segments (2); 1995, yeast artificial chromosome (YAC) sequence tagged sites (STS) content map (3).
Figure 2
Figure 2
Interference by recombination density.
See this image and copyright information in PMC

References

    1. McKusick V A. In: Genetic Maps. 5th Ed. O’Brien S J, editor. Plainview, NY: Cold Spring Harbor Lab. Press; 1990. pp. 5047–5133.
    1. Bowcock A M, Bakker B, Ceverha P, Chipperfield M A, Minter-Morrison A, Porter C J, Pearson P L. Report of the DNA Committee: Human Gene Mapping 1993. Baltimore: Johns Hopkins Univ. Press; 1994. pp. 893–972.
    1. Hudson T J, Stein L D, Gerety S S, Ma J, Castle A B, et al. Science. 1995;270:1945–1954. - PubMed
    1. Anonymous Human Genome News. 1995;7:1–9.
    1. Morton N E, Collins A, Lawrence S, Shields D C. Ann Hum Genet. 1992;56:223–232. - PubMed

LinkOut - more resources