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. 1996 Jul;37(7):1127-9.

Skeletal muscle uptake of fluorine-18-FDG: effect of oral diazepam

S F Barrington  1 , M N Maisey
Affiliations
  • PMID: 8965182

Skeletal muscle uptake of fluorine-18-FDG: effect of oral diazepam

S F Barrington et al. J Nucl Med. 1996 Jul.

Abstract

We have observed a pattern of symmetrically increased uptake of [18F]fluorodeoxyglucose (FDG) in the neck and thoracic paravertebral regions of several patients referred for whole-body PET. The distribution is suggestive of uptake in contracting skeletal muscle in tense patients.

Methods: To test this hypothesis, six successive patients who exhibited this pattern of uptake underwent rescanning using an identical imaging protocol but with oral diazepam before injection of FDG.

Results: The increased neck and paravertebral uptake was significantly reduced or abolished with diazepam, confirming the supposition that this increased neck and paravertebral uptake represents a normal variant of muscle uptake.

Conclusion: Oral diazepam, given before the uptake period can be helpful in such patients to exclude the masking of potential abnormalities by this characteristic pattern of FDG uptake.

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