Review
doi: 10.1016/s1359-6101(96)00030-5.
The immunology of Eta-1/osteopontin
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- PMID: 8971479
- DOI: 10.1016/s1359-6101(96)00030-5
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Review
The immunology of Eta-1/osteopontin
Cytokine Growth Factor Rev.
1996 Oct.
Abstract
The cytokine Eta-1/osteopontin is secreted by activated macrophages and may constitute the most abundant molecule secreted by activated T-lymphocytes. It causes macrophages to migrate and suppress production of reactive oxygen species. It enhances generation of immunoglobulins or proliferation of B-lymphocytes. Its biochemical characteristics suggest that Eta-1/osteopontin may be the T-lymphocyte suppressor factor. The apparently conflicting effects on individual immune functions may reflect homeostatic mechanisms.
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