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Review
. 1996 Oct;7(3):241-8.
doi: 10.1016/s1359-6101(96)00030-5.

The immunology of Eta-1/osteopontin

G F Weber  1 , H Cantor
Affiliations
Review

The immunology of Eta-1/osteopontin

G F Weber et al. Cytokine Growth Factor Rev. 1996 Oct.

Abstract

The cytokine Eta-1/osteopontin is secreted by activated macrophages and may constitute the most abundant molecule secreted by activated T-lymphocytes. It causes macrophages to migrate and suppress production of reactive oxygen species. It enhances generation of immunoglobulins or proliferation of B-lymphocytes. Its biochemical characteristics suggest that Eta-1/osteopontin may be the T-lymphocyte suppressor factor. The apparently conflicting effects on individual immune functions may reflect homeostatic mechanisms.

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