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Clinical Trial
. 1996 Nov;21(5):321-4.

Enhanced calcium response to serotonin in platelets from patients with affective disorders

S Yamawaki  1 , A Kagaya, Y Okamoto, M Shimizu, A Nishida, Y Uchitomi
Affiliations
Clinical Trial

Enhanced calcium response to serotonin in platelets from patients with affective disorders

S Yamawaki et al. J Psychiatry Neurosci. 1996 Nov.

Abstract

In this report we have investigated the intracellular calcium (Ca2+) mobilization mediated by serotonin 5-HT2A receptors in the platelets of 13 patients with bipolar disorder and 12 patients with major depression in comparison with 15 healthy control subjects. We found an enhanced intracellular Ca2+ rise in response to 5-HT in platelets from both bipolar patients and patients with major depression. The 5-HT2A receptor-mediated intracellular Ca2+ signaling mechanism may have an important role in the pathophysiology of affective disorders.

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