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Clinical Trial
. 1996 Nov;55(11):811-5.
doi: 10.1136/ard.55.11.811.

Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis

A Booji  1 , C M Biewenga-Booji, O Huber-Bruning, C Cornelis, J W Jacobs, J W Bijlsma
Affiliations
Clinical Trial

Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis

A Booji et al. Ann Rheum Dis. 1996 Nov.

Abstract

Objective: To examine the possible beneficial effect of androgens in postmenopausal women with active rheumatoid arthritis.

Methods: 107 women participated in a double blind placebo controlled trial to evaluate the effect of 50 mg testosterone propionate intramuscularly every two weeks for one year.

Results: An improvement in ESR, Dutch health assessment questionnaire, and pain was noted. In addition, 21% of patients treated with testosterone fulfilled the ACR improvement criteria after one year, versus only 4% of the placebo group. The treatment was well tolerated.

Conclusions: Testosterone may improve the general wellbeing of postmenopausal women with active rheumatoid arthritis.

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References

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    1. Arthritis Rheum. 1988 Mar;31(3):315-24 - PubMed
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