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. 1996 Oct;180(2):181-7.
doi: 10.1002/(SICI)1096-9896(199610)180:2<181::AID-PATH620>3.0.CO;2-I.

Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis

V Rai  1 , J Hopkisson, S Kennedy, A Bergqvist, D H Barlow, H J Mardon
Affiliations

Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis

V Rai et al. J Pathol. 1996 Oct.

Abstract

The expression of integrin subunits has been investigated in the stroma and epithelium of eutopic and ectopic endometrial tissues, using immunohistochemistry and fluorescently activated cell-sorting techniques. Integrin subunits exhibited tissue-specific expression in both eutopic and ectopic endometrium. Integrin alpha 3 subunit was up-regulated in ectopic endometrium compared with the eutopic counterpart, whereas alpha 6 integrin subunit was down-regulated in the ectopic tissues. Cycle stage-dependent expression of alpha v and beta 3, observed in eutopic endometrium, was absent in the ectopic counterpart. It is concluded that the development and regeneration of the endometrium involve complex integrin-ligand interactions and that regulation of specific adhesive events is lost in endometriosis.

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