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Review
. 1996 Jun;44(6):564-70.

[Circadian rhythms in hepatic biotransformation of drugs]

[Article in French]
P M Bélanger  1
Affiliations
  • PMID: 8977913
Review

[Circadian rhythms in hepatic biotransformation of drugs]

[Article in French]
P M Bélanger. Pathol Biol (Paris). 1996 Jun.

Abstract

The temporal variations in hepatic drug biotransformation are reviewed. Important diurnal variations in the activity of different cytochrome P-450 isoenzymes and in enzyme systems involved in conjugation to glucuronide, sulfate and acetate are described. A circadian rhythm in the hepatic concentration of glutathione is also described. These temporal variations explain the chronopharmacokinetic and chronohepatotoxicity of some drugs or toxic agents.

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