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. 1996 Dec 27;87(7):1249-60.
doi: 10.1016/s0092-8674(00)81820-6.

RSC, an essential, abundant chromatin-remodeling complex

B R Cairns  1 , Y Lorch, Y Li, M Zhang, L Lacomis, H Erdjument-Bromage, P Tempst, J Du, B Laurent, R D Kornberg
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Free article

RSC, an essential, abundant chromatin-remodeling complex

B R Cairns et al. Cell. .
Free article

Abstract

A novel 15-subunit complex with the capacity to remodel the structure of chromatin, termed RSC, has been isolated from S. cerevisiae on the basis of homology to the SWI/SNF complex. At least three RSC subunits are related to SWI/SNF polypeptides: Sth1p, Rsc6p, and Rsc8p are significantly similar to Swi2/Snf2p, Swp73p, and Swi3p, respectively, and were identified by mass spectrometric and sequence analysis of peptide fragments. Like SWI/SNF, RSC exhibits a DNA-dependent ATPase activity stimulated by both free and nucleosomal DNA and a capacity to perturb nucleosome structure. RSC is, however, at least 10-fold more abundant than SWI/SNF complex and is essential for mitotic growth. Contrary to a report for SWII/SNF complex, no association of RSC (nor of SWI/SNF complex) with RNA polymerase II holoenzyme was detected.

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