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. 1996 Dec 27;87(7):1327-38.
doi: 10.1016/s0092-8674(00)81827-9.

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

J Z Tsien  1 , P T Huerta, S Tonegawa
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Free article

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

J Z Tsien et al. Cell. .
Free article

Abstract

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.

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