[Chorioretinal lymphoproliferative disorder induced by Epstein-Barr virus in lung transplantation]

Abstract

The Epstein-Barr virus (EBV) is the causative factor of the posttransplant lymphoproliferative syndromes. Some ocular cases were described. We report the case of a lung-transplanted 59 year old man who presented a chorioretinal lymphoproliferative syndrome. A B-cell monoclonality and numerous EBV genome copies were demonstrated in vitreous material by PCR. We suspect an intermediate stage between polyclonal lymphoproliferative syndrome and malignant lymphoma. A treatment with nucleoside analogs and immunosuppression decrease was successful. The positive clinical evolution was associated with a reduction of the EBV genome quantity.