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Clinical Trial
. 1995 Oct;32(10):1077-82.

Evaluation of immunogenicity and tolerance of single dose haemophilus influenzae type B (PRP-T) vaccine

D Acharya  1 , A Desai, N Nanavaty, A Pandit, V Patel, J Shah, N Shendurnikar, S Singh, A Taneja, S Vani
Affiliations
  • PMID: 8984044
Clinical Trial

Evaluation of immunogenicity and tolerance of single dose haemophilus influenzae type B (PRP-T) vaccine

D Acharya et al. Indian Pediatr. 1995 Oct.

Abstract

Objective: Evaluation of immunogenicity and acceptability of PRP-T vaccine among the Indian children.

Design: Multicentric, open, parallel group, comparative study of Haemophilus influenzae type B vaccine, given as single (Group I) or associated (Group II) with DPT vaccine.

Setting: Five different vaccination clinics.

Subjects: 125 children between the age group of 18-24 months.

Parameters: Measurement of (i) pre and post vaccination antibody titres of Haemophilus influenze type B specific antibody; (ii) Adverse events; and (iii) Tolerance as graded by the physician.

Results: Prevaccination antibody levels were > 0.15 mcg/ml in 56.3% in Group I and 35.7% in Group II. Post-seroconversion was seen in 97% in Group II receiving single and all in Group II (P > 0.05). The vaccine was well tolerated.

Conclusions: The probability of subclinical infection or cross immunity is high in India. ACTHIB vaccine has a good immunogenicity and tolerance and association with DPT does not modify the immunogenicity of ACTHIB vaccine.

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