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. 1997 Jan;71(1):824-7.
doi: 10.1128/JVI.71.1.824-827.1997.

Murine coronavirus packaging signal confers packaging to nonviral RNA

K Woo  1 , M Joo, K Narayanan, K H Kim, S Makino
Affiliations

Murine coronavirus packaging signal confers packaging to nonviral RNA

K Woo et al. J Virol. 1997 Jan.

Abstract

Studies of defective interfering (DI) RNAs of the murine coronavirus mouse hepatitis virus (MHV) suggest that a 69-nucleotide-long packaging signal is necessary for MHV genomic RNA packaging into MHV particles. In this study we showed that when RNA transcripts that consisted of a non-MHV sequence and the packaging signal were expressed in MHV-infected cells, they were packaged into MHV particles. Those RNA transcripts that lacked the packaging signal or those containing a mutated packaging signal did not package efficiently. Thus, the presence of the packaging signal was sufficient for RNA packaging into MHV particles.

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