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Case Reports
. 1996 Nov;11(11):1012-5.
doi: 10.1111/j.1440-1746.1996.tb00023.x.

Case report: agranulocytosis induced by interferon-alpha therapy for chronic hepatitis C

Y Higashi  1 , K Sakai, S Tada, S Miyase, T Nakamura, T Kamio, O Haraguchi
Affiliations
Case Reports

Case report: agranulocytosis induced by interferon-alpha therapy for chronic hepatitis C

Y Higashi et al. J Gastroenterol Hepatol. 1996 Nov.

Abstract

A 60-year-old woman presented with chronic active hepatitis C whose HCV-RNA genotype was II according to Okamoto's classification and serum HCV-RNA concentration was 10(4) copies/mL. Agranulocytosis was induced 13 days from the commencement of interferon (IFN)-alpha 2b (6 MU/day) therapy, so the IFN therapy was immediately discontinued. The agranulocytosis improved rapidly with the administration of a granulocyte colony stimulating factor (G-CSF). The possibility that IFN was associated with maturational arrest of myeloid progenitor cells was considered. During the course of 3 years of follow-up, her liver function has remained normal and serum HCV-RNA remains negative.

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