Effects of toyocamycin on the biological activity of a murine oncornavirus produced by a chronically infected cell line
- PMID: 89874
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Effects of toyocamycin on the biological activity of a murine oncornavirus produced by a chronically infected cell line
Biomedicine.
1979 Feb.
Abstract
Production of Friend virus by chronically infected cells (Friend-Eveline cell line) is depressed by Toyocamycin, an adenosine analogue, at doses which stop cellular growth. The infectivity and the endogenous reverse transcriptase activity of the virions are diminished. These effects are likely to be due to the incorporation of Toyocamycin into the 70S RNA.
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