Antimutagenic effect of methanolic extracts from peanut hulls
- PMID: 8987671
- DOI: 10.1271/bbb.60.1698
Antimutagenic effect of methanolic extracts from peanut hulls
Abstract
The antimutagenic effects of methanolic extracts of peanut hulls (MEPH) were evaluated by the Ames test. MEPH inhibited the mutagenicity of 4-nitroquinoline-N-oxide (NQNO), a direct-acting mutagen. MEPH also inhibited the mutagenicity of some indirect-acting mutagens and decreased in the order of 2-amino-3-methyl-imidazo(4,5-f)quinoline (IQ) > aflatoxin B1 (AFB1) > 2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole (Glu-P-1) > 3 amino-1,4-dimethyl-5H-pyridol(4,3-b)indole (Trp-P-1) > benzo(a)pyrene (B(a)P for S. typhimurium TA98, and IQ > Trp-P-1 > Glu-P-1 > AFB1 > B(a)P for S. typhimurium TA100.
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