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. 1997 Jan;4(1):39-43.
doi: 10.1038/nsb0197-39.

Projection structure of a gap junction membrane channel at 7 A resolution

V M Unger, N M Kumar, N B Gilula, M Yeager

Projection structure of a gap junction membrane channel at 7 A resolution

V M Unger et al. Nat Struct Biol. 1997 Jan.

Abstract

Electron cryo-microscopy and image analysis of frozen-hydrated, two-dimensional crystals of gap junction membrane channels formed by recombinant alpha 1 connexin (Cx43) reveal a ring of transmembrane alpha-helices that lines the aqueous pore and a second ring of alpha-helices in close contact with the membrane lipids.

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