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. 1997 Jan 7;94(1):148-50.
doi: 10.1073/pnas.94.1.148.

Two-state models of protein folding kinetics

R Zwanzig  1
Affiliations

Two-state models of protein folding kinetics

R Zwanzig. Proc Natl Acad Sci U S A. .

Abstract

The folding of some proteins appears to be a two-state kinetic process. A two-state kinetic model is justified if protein molecules rapidly equilibrate between different unfolded conformations prior to complete folding. Here I show that this rapid equilibration is a natural consequence of reasonable assumptions about reaction rate constants and folding thermodynamics.

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