Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells
- PMID: 8991383
- DOI: 10.1016/0167-5699(96)10011-6
Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells
Abstract
Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8+ T-cell antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and colleagues propose that this antiviral activity represents a natural cellular immune reaction that controls HIV production and protects the host from potential harmful effects of cytotoxic T lymphocytes.
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