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Review
. 1996 May;17(5):217-24.
doi: 10.1016/0167-5699(96)10011-6.

Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells

Affiliations
Review

Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells

J A Levy et al. Immunol Today. 1996 May.

Abstract

Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8+ T-cell antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and colleagues propose that this antiviral activity represents a natural cellular immune reaction that controls HIV production and protects the host from potential harmful effects of cytotoxic T lymphocytes.

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