Review
doi: 10.1016/s0959-440x(96)80013-3.
New structures of allosteric proteins revealing remarkable conformational changes
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- PMID: 8994883
- DOI: 10.1016/s0959-440x(96)80013-3
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Review
New structures of allosteric proteins revealing remarkable conformational changes
Curr Opin Struct Biol.
1996 Dec.
Abstract
New three-dimensional structures of allosteric proteins reveal they have a flexible architecture that is instrumental to the regulation of protein function. Highlights are the structures of GroEL, pyruvate kinase, D-3-phosphoglycerate dehydrogenase and the acetylcholine receptor. Furthermore, significant progress in understanding the nature of the intermediates involved in an allosteric reaction has been achieved through recent spectroscopic and crystallographic studies on haemoglobin.
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