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Review
. 1996 Dec 15;4(12):1381-5.
doi: 10.1016/s0969-2126(96)00145-1.

Precluding uracil from DNA

D G Vassylyev  1 , K Morikawa
Affiliations
Free article
Review

Precluding uracil from DNA

D G Vassylyev et al. Structure. .
Free article

Abstract

Two enzymes, dUTP pyrophosphatase and uracil-DNA glycosylase, prevent the misincorporation of uracil into the genome in distinct manners. The atomic structures of these proteins complexed with substrate analogs reveal the structural basis for uracil recognition and suggest a novel mechanism of DNA repair.

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