[Correlation of immunologic and pathomorphologic shifts in mother and fetus following experimental neurosensitization]

Abstract

The authors studied mother-rats and their fetuses during the 3 main stages of pregnancy in a sensitation of the rats to homologous brain antigens. Such studies were performed by means of immunological, visual, neurohistological and cytochemical methods. Dystrophical changes were found in the brain of mother-rats and the foetus, while as inflammatory reactions and immunocompetent cells were not seen. The regularities which were detected in the correlative interconnections between the degree and character of immune reactions, the viability of the foetuses, morphological changes and the character of reactions of lysosomal enzymes speak in favour of immune genesis. It appears in the first period and especially in the second period of embryogenesis in nonviability of the foetus and dystrophic brain pathology in the mother and foetus.