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. 1978;100(1):85-94.
doi: 10.1159/000144885.

Effects of mitomycin C in postnatal tooth development in mice with special reference to neural crest cells

T Nozue, T Kayano

Effects of mitomycin C in postnatal tooth development in mice with special reference to neural crest cells

T Nozue et al. Acta Anat (Basel). 1978.

Abstract

Neural crest cells in the pre- and postnatal development of mice showed a specific sensitivity to mitomycin C. In mice injected with mitomycin C 24-48 h after birth and surviving up to the 9th day, a free or attached denticle in the pulp and a fibroma or excessive cell proliferation in the dental follicle or the periodontal ligament were seen; further, a dentinoma developed.

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