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. 1996 Nov;15(11):882-4.
doi: 10.1007/BF01691223.

Modified enzyme immunoassay to detect hepatitis C virus antibodies in oral fluid

P G McIntyre  1 , J Laszlo, K Appleyard, G R Ogden
Affiliations

Modified enzyme immunoassay to detect hepatitis C virus antibodies in oral fluid

P G McIntyre et al. Eur J Clin Microbiol Infect Dis. 1996 Nov.

Abstract

Samples of oral fluid collected from 18 patients seropositive for hepatitis C virus (HCV) and 49 seronegative patients were tested for the presence of HCV antibodies with two modified serum-screening kits. The following sensitivities and specificities were obtained: HCV 3.0 assay, 72% and 98%, respectively, and Monolisa anti-HCV assay, 100%, and 100%, respectively. The modified Monolisa assay demonstrated a striking concordance between serum and saliva samples. The use of oral fluids offers a convenient and noninvasive method applicable to HCV epidemiological studies and screening of high-risk groups.

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