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. 1997 Jan 10;275(5297):206-9.
doi: 10.1126/science.275.5297.206.

Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme

Y Gu  1 , K Kuida, H Tsutsui, G Ku, K Hsiao, M A Fleming, N Hayashi, K Higashino, H Okamura, K Nakanishi, M Kurimoto, T Tanimoto, R A Flavell, V Sato, M W Harding, D J Livingston, M S Su
Affiliations

Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme

Y Gu et al. Science. .

Abstract

The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock.

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