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Review
. 1996 Dec;3(12):967-72.
doi: 10.1016/s1074-5521(96)90163-5.

Structure-function analysis of the cloned opiate receptors: peptide and small molecule interactions

A D Blake  1 , G Bot, T Reisine
Affiliations
Review

Structure-function analysis of the cloned opiate receptors: peptide and small molecule interactions

A D Blake et al. Chem Biol. 1996 Dec.

Abstract

Opiate receptors mediate the physiological actions of opioid peptides and the clinical effects of the synthetic opioid agonists and antagonists. Site-directed mutagenesis studies have revealed regions of opiate receptors that are essential for ligand recognition, and this could aid the design of more selective opioid ligands.

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