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Review
. 1996 Dec;3(12):973-80.
doi: 10.1016/s1074-5521(96)90164-7.

Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design

J E Ladbury  1
Affiliations
Review

Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design

J E Ladbury. Chem Biol. 1996 Dec.

Abstract

Recent data have highlighted the enigmatic role that water plays in biomolecular complexes. Water at the interface of a complex can increase the promiscuity of an interaction, yet it can also provide increased specificity and affinity. The ability to engineer water-binding sites into the interface between a drug and its target might prove useful in drug design.

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