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. 1997 Jan 15;63(1):1-6.
doi: 10.1097/00007890-199701150-00002.

FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts

S J Knechtle  1 , D Vargo, J Fechner, Y Zhai, J Wang, M J Hanaway, J Scharff, H Hu, L Knapp, D Watkins, D M Neville Jr
Affiliations

FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts

S J Knechtle et al. Transplantation. .

Abstract

Background: Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model.

Methods: In order to ablate recipient T cells, the immunotoxin FN18-CRM9 was administered to rhesus monkey recipients of MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals.

Results: All monkeys with T-cell depletion by immunotoxin had prolonged allograft survival, and tolerance confirmed by skin grafting has been confirmed in five of six long-surviving recipients.

Conclusions: In this clinically relevant model, profound but transient T-cell depletion by a single agent substantially promotes tolerance.

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