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Clinical Trial
. 1997 Jan;130(1):86-8.
doi: 10.1016/s0022-3476(97)70314-7.

Evaluation of a new method of administration of the iron chelating agent deferoxamine

C Borgna-Pignatti  1 , A Cohen
Affiliations
Clinical Trial

Evaluation of a new method of administration of the iron chelating agent deferoxamine

C Borgna-Pignatti et al. J Pediatr. 1997 Jan.

Abstract

We compared the effectiveness of deferoxamine administered by twice-daily subcutaneous injections with conventional administration by prolonged subcutaneous infusion in 20 patients with thalassemia. Urinary iron excretion was comparable with the two methods but decreased significantly when the total daily dose was administered as a single injection. Local reactions were similar with infusion and injection. Subcutaneous injections of deferoxamine may be considered as an alternative to conventional infusions.

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