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. 1996 Dec;33(12):1043-4.
doi: 10.1136/jmg.33.12.1043.

Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31

D Avramopoulos  1 , G Kitsos, E Economou-Petersen, M Grigoriadou, D Vassilopoulos, C Papageorgiou, K Psilas, M B Petersen
Affiliations

Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31

D Avramopoulos et al. J Med Genet. 1996 Dec.

Abstract

A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

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