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Review
. 1996 Nov;23(8):957-80.
doi: 10.1016/s0969-8051(96)00130-8.

Copper radionuclides and radiopharmaceuticals in nuclear medicine

P J Blower  1 , J S Lewis, J Zweit
Affiliations
Review

Copper radionuclides and radiopharmaceuticals in nuclear medicine

P J Blower et al. Nucl Med Biol. 1996 Nov.

Abstract

The chemistry, radiochemistry, radiobiology, and radiopharmacology of radiopharmaceuticals containing copper radionuclides are reviewed. Copper radionuclides offer application in positron emission tomography, targeted radiotherapy, and single photon imaging. The chemistry of copper is relatively simple and well-suited to radiopharmaceutical application. Current radiopharmaceuticals include biomolecules labelled via bifunctional chelators primarily based on cyclic polyaminocarboxylates and polyamines, and pyruvaldehyde-bis(N4-methylthiosemicarbazone) (PTSM) and its analogues. The chemistry of copper, of which only a fraction has yet been exploited, is likely to be applied more fully in the future.

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