[Treatment of Flexner's dysentery with ofloxacin]

Abstract

Twenty four patients with dysentery due to Shigella flexneri2a and 1 patient with mixed infection (acute dysentery due to Sh.flexneri 2a+group B salmonellosis) were treated with ofloxacin. The patients were divided into 4 groups. In group I ofloxacin was administered intravenously in a dose of 200 mg twice a day followed by its oral use in the form of tablets in a dose of 200 mg twice a day for 5 to 6 days. In group II ofloxacin was used orally in the form of tablets in a dose of 200 mg once a day in the morning for 5 to 7 days. In group III ofloxacin was used in the same dosage but in combination with some other antibiotics. In group IV the patients were treated with antibiotics except for ofloxacin. High efficacy of ofloxacin was observed with all the regimens. In the patients treated with ofloxacin rapid improvement of the patient state (normalization of the body temperature by the 2nd or 3rd day) and complete eradication of the pathogens were recorded. Ofloxacin was superior by the efficacy to the other antibiotics.