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. 1977 Aug;12(2):192-4.
doi: 10.1128/AAC.12.2.192.

In vitro uptake of gentamicin by rat renal cortical tissue

C H Hsu, T W Kurtz, J M Weller

In vitro uptake of gentamicin by rat renal cortical tissue

C H Hsu et al. Antimicrob Agents Chemother. 1977 Aug.

Abstract

The mechanism of gentamicin uptake in vitro by renal cortical slices of rat kidney was investigated. The cortical-slice-uptake ratio of gentamicin concentration in 1.0 g of tissue water to that of 1.0 ml of incubation medium (SW/M) was 1.44 +/- 0.04. The uptake of gentamicin was inhibited by 2 x 10(-5) M dinitrophenol (SW/M = 1.03 +/- 0.04) and by anoxia (SW/M = 1.01 +/- 0.04). The results indicate that aerobic phosphorylation is required to transport gentamicin into the cells. The uptake of p-aminohippurate and tetraethylammonium chloride by renal cortical slices was not affected by gentamicin.

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References

    1. Am J Physiol. 1950 Apr 1;161(1):181-90 - PubMed
    1. Am J Med. 1964 May;36:743-62 - PubMed
    1. Kidney Int. 1976 Dec;10(6):444-9 - PubMed
    1. Kidney Int. 1974 Sep;6(3):131-7 - PubMed
    1. J Infect Dis. 1974 Dec;130(6):656-9 - PubMed

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