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Comparative Study
. 1997 Feb;65(2):843-6.
doi: 10.1128/iai.65.2.843-846.1997.

Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion

S P Cole  1 , D Cirillo, M F Kagnoff, D G Guiney, L Eckmann
Affiliations
Comparative Study

Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion

S P Cole et al. Infect Immun. 1997 Feb.

Abstract

Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic significances are unknown. Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells.

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