Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1996 Dec;21(12):460-6.
doi: 10.1016/s0968-0004(96)20026-x.

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

J E Ferrell Jr  1
Affiliations
Free article
Review

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

J E Ferrell Jr. Trends Biochem Sci. 1996 Dec.
Free article

Abstract

Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources